Basic Dental Science (Cancer Studies) PhD – (M.Phil.)

Research within Cancer Studies aims to understand the molecular pathology of head and neck cancers, primarily squamous cell carcinoma but also malignant salivary gland tumours. A major focus of our current work is verifying at molecular and functional level, the role of candidate genes identified through high density SNP array analyses of these tumours. At molecular level, this involves mutation-, quantitative expression- and promoter hypermethylation-analyses. At functional level, this is involves assaying phenotypic effects of modulating expression of the candidate genes and identifying pathways in which the proteins encoded by these genes act. Promising candidates are tested further for correlation of expression with clinical parameters and potential validation as biomarkers.

PhD study within the School is a challenging yet rewarding experience. Flexibility is allowed within the parameters of the study to allow the research to evolve and instigate findings not envisaged at the outset of the work. This is complimented by a dedicated PhD training structure, which provides critical skills training, personal development and progression milestones.

The PhD project will either be outlined by the academic supervisor offering the study or, alternatively, by an applicant seeking to work within a particular research area with a focused plan of research in mind. The supervisory team will assist the PhD applicant throughout the study ensuring academic objectives are met and suitable training is provided in core skills fundamental to the research. Transferable skills training is provided by a dedicated Graduate Training Programme offered by the Faculty of Medical and Human Sciences, which provides training in research methodology, critical writing skills, intellectual property, research ethics etc.

Students are expected to attend journal clubs, research meetings and talks within the School and University.