M.Sc. Toxicology

  • On Campus
  • 12 months
  • GBP17960 Year (Non-EEA)
  • English
University of Birmingham | Birmingham, United Kingdom
This programme provides vocational training in the theoretical, clinical and laboratory aspects of toxicology. You will learn about the nature and mechanism of adverse effects of chemicals such as those found in industry, in the household, in agriculture, in medicine and those that occur naturally in the environment. We give particular emphasis to molecular and cellular mechanisms of toxicity and to risk assessment.

Description of Toxicology

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This programme acts as a conversion course taking students at entry from a variety of backgrounds and giving them new skills to enable them to move into research and employment in a number of disciplines.

Specific programme aims

The MSc in Toxicology programme aims to:

  • provide a broad, modern training in theoretical and practical aspects of fundamental and applied toxicology
  • prepare individuals to collate, interpret and communicate toxicological information
  • provide an opportunity to study at the cutting edge of research in a chosen specialist field of toxicology
  • develop student awareness of the importance of toxicology to industry, health, the environment and society

Detailed Course Facts

Tuition fee
  • GBP 17960 Year (Non-EEA)
  • GBP 6480 Year (EEA)
Start date September  2015
Duration full-time 12 months
Languages
  • English
Take an IELTS test
Delivery mode On Campus
Educational variant Full-time

Course Content

Modules

The MSc programme is of 12 months duration commencing in late September, and comprises four taught modules, a skills module, a synoptic module and a research project. To accommodate students who might be released from their posts in industry for short periods, or those wishing to undertake part-time study for other reasons, modules can also be taken separately over a period of 2 years.

The taught modules (5 or 6 weeks long) are as follows (descriptions below):

  • Module 1 Metabolism and excretion of xenobiotics
  • Module 2 Pharmacological, forensic and clinical aspects of toxicology
  • Module 3 Molecular and cellular mechanisms of toxicity and carcinogenesis
  • Module 4 Toxicology in Practice: Safety assessment in industry and the environment

Generic and specific skills training is embedded throughout the taught modules, and during the year you will visit a number of external establishments involved with toxicology. The research project (12 weeks from May to August) takes place in a university, research institute, industry or a hospital environment. Many take place away from the University and/or Birmingham giving you the opportunity to experience other working environments.

Module 1: Metabolism and excretion of xenobiotics

The module describes the disposition of foreign compounds within the body of living organisms. It covers the methods used to study xenobiotic metabolism; their absorption and distribution and excretion, and includes the application of molecular biology techniques to drug metabolism and pharmacogenetics.

The major metabolic pathways are described including phase I and phase II reactions. The effect of species, age, sex and nutrition on these reactions is included. Metabolism and distribution are discussed as a basis for the toxicity of a range of xenobiotics.

Module 2: Pharmacological, forensic and clinical aspects of toxicology

This six week module consists of two weeks of lectures in clinical pharmacology / forensic toxicology and two weeks of lectures in clinical toxicology. The lectures are given by clinicians and research staff from the Division of Medical Sciences at the University of Birmingham, the Regional Toxicology Laboratories and the National Poisons Information Service/West Midlands Poisons Unit as well as external lectures from industry.

The module covers the principles of pharmacokinetics, pharmacodynamics and pharmacogenetics in the context of drug development and adverse drug reactions. The effects of poisoning with a wide range of pharmacological and chemical agents are detailed along with aspects of diagnosis and management. Methods used to detect drugs of abuse and other toxic agents are described together with their application in investigation of deaths

Module 3: Molecular and cellular mechanisms of toxicity and carcinogenesis

The module describes molecular mechanisms of toxicity, including the induction of necrosis and apoptosis, by such processes as covalent binding oxidative toxicity, lipid peroxidation, aberrant Ca2+ status, receptor interactions and altered gene expression.

The mechanisms of carcinogenesis are covered and include the contribution of oncogenes, tumour suppressor genes in cell cycle control. DNA damage and mutations are considered alongside non-genotoxic influences on carcinogenesis including the action of peroxisome proliferators.

Specialised topics such as immunotoxicity and in vitro toxicity testing are included as is a computer-assisted study on structure toxicity relationships. Recent developments in high throughput screening and the application of molecular biology including genomics, transcriptomics, proteomics and metabolomics to toxicology are discussed.

Module 4: Toxicology in Practice; safety assessment in industry and the environment

The module focuses on the assessment of chemical toxicity and includes core training in the statistical analysis required to undertake this successfully. Students learn how to detect acute and chronic toxicity in animal studies with emphasis been placed on pathological responses to toxic substances in different organ systems (e.g. kidney, liver, lung, blood). Students will learn to recognise acute and chronic inflammation, necrosis, neoplasia, hypertrophy and other cellular changes as demonstrated by histology. Students will also consider the choice of experimental species to demonstrate toxicity and reproductive toxicology where the effects of toxic compounds on fertility and embryogenesis will be discussed.

The second part of the module centres on Occupational and Environmental Toxicology. Students are taught how toxic compounds can lead to occupational disease and how this is assessed and managed by monitoring, epidemiological studies and the setting of appropriate safety standards in the work place. Students also consider the effects of chemicals on the environment. Air, water and land contamination and effect on humans and non human species is investigated. This includes lectures on assessment procedures, regulatory aspects and environmental control and remediation.

English Language Requirements

CAE score
200(Grade A)

Requirements for Toxicology

A good Honours degree in Biochemistry, Biology, Chemistry, Pharmacology, Pharmacy, Physiology or a related discipline. Alternatively you may be qualified in Medicine or Veterinary Science. Graduates without Honours but with at least two years approved postgraduate experience may also be considered.

Work Experience for Toxicology

No work experience is required.

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